Observations on the Wassermann Reaction

نویسندگان

  • Paul A. Lewis
  • H. S. Newcomer
چکیده

The Wassermann reaction carried out according to the method of McIntosh and Fildes, with cholesterolized antigen and with certain allowances for the presence of native anti-sheep amboceptor; leads to about the same result as when it is done according to the recent proposal of Noguchi, with the native human complement and acetone-insoluble lipoids as antigen. The differences are such as to suggest that from the point of view of diagnosis the Noguchi method is the more conservative but that there is definite advantage in using two metnods as distinct in origin of materials as these, partly for the purpose of control and partly in the hope of acquiring new information of importance. As a measure of control of treatment the cholesterol antigen appears to us to be the more valuable. The Wassermann reaction alone, by whatever method it may be done, can only be used in the diagnosis of syphilis in conjunction with presumption based on other grounds. That it fails to appear in a considerable percentage of syphilitics is well known. That the reaction is positive in other conditions is not so generally recognized. Fresh instances of this in certain febrile cases are here recorded.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Serological Wassermann problem cases.

The subject of Wassermann "Problem" cases is of interest not only to the serologist but to the physician or clinician, upon whom devolves the responsibility for diagnosis. In the past there has been too little critical judgment by clinicians in assessing the results of the Wassermann reaction, and many practitioners may still regard a positive Wassermann reaction as in itself a diagnosis of syp...

متن کامل

Automated screening method for the Wassermann reaction.

For a number of years we have considered the Wassermann reaction to be eminently suitable for complete automation. It was after our experience with the Technicon Autoanalyser doing chemical analyses that we decided to experiment with the Wassermann reaction. The following paper records the details of our method, based on the Whitechapel technique (Wilkinson, 1962). It does not include details o...

متن کامل

Complement Deviation in Scarlet Fever with Comparative Studies of the Wassermann and Noguchi Systems

The Wassermann reaction in scarlet fever per se is uniformly negative. The antigen of scarlet fever liver yields practically the same results as that of luetic liver, and both fail to deviate complement with scarlet fever antibodies. The Noguchi reaction in scarlet fever is practically negative. Sixteen cases, or 6.4 per cent. of 250 cases, were positive when active serum was used; with inactiv...

متن کامل

the Butyric Acid Test for Syphilis in the Diagnosis of Metasyphilitic and Other Nervous Disorders

1. In the secondary and tertiary stages of syphilis without direct involvement of the nervous system the cerebro-spinal fluid yielded the butyric acid reaction of feeble intensity. The fluid under these conditions gave neither a positive cytodiagnosis nor the Wassermann test for syphilis. 2. The cerebro-spinal fluid of cases of hereditary syphilis showed a positive butyric reaction in about 90 ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • The Journal of Experimental Medicine

دوره 29  شماره 

صفحات  -

تاریخ انتشار 2003